Robust Age at Onset Linkage Analysis in Nuclear Families
نویسندگان
چکیده
منابع مشابه
Robust age at onset linkage analysis in nuclear families.
OBJECTIVE Standard methods for linkage analysis ignore the phenotype of the parents when they are not genotyped. However, this information can be useful for gene mapping. In this paper we propose methods for age at onset genetic linkage analysis in sibling pairs, taking into account parental age at onset. METHODS Two new score statistics are derived, one from an additive gamma frailty model a...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2010
ISSN: 1423-0062,0001-5652
DOI: 10.1159/000264446